Unfortunately, these tools typically operate with one protein structure. PROMOTIF Hutchinson and Thornton, 1996, Pro-origami Stivala et al., 2011, HERA Hutchinson and Thornton, 1990). Several tools for the 2D visualization of protein secondary structure have been developed (e.g. The most straightforward way to compare protein structures within a protein family might be its visualization using secondary structure 2D diagrams. These data provide us with a robust basis for examining individual protein families, discovering their essential parts and understanding their structure-function relationships.Ī key insight into the structure of a protein is often provided by the visualization of its secondary structures, i.e., the spatial organization of its secondary structure elements (SSEs) such as α-helices and ß-sheets. These structures originate from different organisms, bind various ligands and contain diverse mutations. Specifically, close to 7000 protein families are listed in the CATH database ( Sillitoe et al., 2021), and, for some of them, hundreds to thousands of their member proteins' structures have been determined. These structural data enabled the establishment of rich datasets describing individual protein families. Nowadays, there are more than 170 000 structures in Protein Data Bank (PDB) ( Armstrong et al., 2020).
0 Comments
Leave a Reply. |